Neuroprotection of Rhizoma Polygonati on Mice with Cognitive Dysfunction Induced by D-Galactose

Cognitive dysfunction (CD) is manifested as forgetfulness and memory loss, accompanied by language, mental, motor dysfunctions etc. Rhizoma Polygonati (RP) a traditional Chinese medicine for both medicinal edible uses in China, which have the functions of improving learning abilities, but neuroprotection on Mice with Dysfunction unclear. In present study, ability processed RP CD mice induced D-galactose (D-gal) was investigated. The results showed that gavage administration could significantly increase new object recognition index improve behavioral through Morris water maze step-down tests. recovered impaired cells hippocampus caused D-gal. enhanced anti-oxidative activity increasing T-AOC decreasing MDA content, inhibited inflammation nervous system declining contents TNF-α IL-6 hippo-campus mice. These indicated had significant protective effect D-gal cognitive